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DOAC·Haematology - Anticoagulants & Haemostatics
Stroke prevention in non-valvular AF, treatment and prevention of DVT/PE
Max Dose
5 mg BD
Half-life
12 h
Bleeding Risk
HIGH
Monitoring
ROUTINE NOT REQ.
Overview
Direct Factor Xa inhibitor. Often preferred for the elderly due to the lowest rate of GI bleeding among the DOACs and lower reliance on renal clearance.
Maximum Dose
Max 5 mg BD.
Clinical Focus
Requires strict BD dosing. If the patient is prone to forgetting doses, Rivaroxaban (OD) is a safer option.
Bottom Line
Apixaban is the DOAC with the best bleeding profile and is preferred in elderly and renally impaired patients, but requires twice-daily dosing and has limited options for reversal.
Brand Names
Eliquis
Oral Routes
Tablets (2.5 mg, 5 mg). Taken with or without food.
Prescribing & PBS
Authority Required (PBS).
Primary
Stroke prevention in non-valvular AF, treatment and prevention of DVT/PE.
Clinical Place
Often the first-line DOAC choice in WA Health for frail, elderly patients due to superior safety profile (ARISTOTLE trial).