Indapamide

Overview

Thiazide-like diuretic. Superior to hydrochlorothiazide for blood pressure lowering with slightly less metabolic disruption (glucose/lipids).

Maximum Dose

Max 2.5 mg/day (IR) or 1.5 mg/day (SR).

Clinical Focus

Preferred over HCTZ in patients with metabolic syndrome or diabetes due to neutrality on glucose tolerance.

Bottom Line

Indapamide is a thiazide-like diuretic with superior stroke prevention evidence (ADVANCE, HYVET), but carries the same electrolyte disturbance risks as conventional thiazides.

Brand Names

Natrilix, Natrilix SR, Coversyl Plus (combo)

Oral Routes

Tablets IR (2.5 mg), Tablets SR (1.5 mg).

Prescribing & PBS

Unrestricted General Benefit (S4).

Primary

Hypertension.

Clinical Place

First-line diuretic option for hypertension. Supported by strong evidence in the elderly (HYVET trial).