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Ultra-Long Basal Insulin·Endocrinology - Insulins & Injectables
Type 1 and Type 2 Diabetes
Max Dose
Titrated
Duration
42 HOURS
Timing
FLEXIBLE
Hypos
LOWER RISK
Overview
Ultra-long-acting basal insulin. Forms multi-hexamer chains under the skin, taking days to absorb. Provides the flattest, most consistent 24-hour profile with the lowest risk of nocturnal hypos.
Maximum Dose
Titrated to fasting BSL.
Clinical Focus
Because it lasts 42 hours, the injection timing is incredibly flexible. A patient can take it at 8 AM one day and 8 PM the next day without risking gaps or overlap.
Bottom Line
Insulin degludec is an ultra-long-acting basal insulin with the lowest hypoglycaemia risk and flexible dosing, but is more expensive and offers marginal benefit over glargine for most patients.
Brand Names
Tresiba
Parenteral
Pre-filled pens for SC injection (100 U/mL). Clear solution.
Prescribing & PBS
Authority Required (PBS).
Primary
Type 1 and Type 2 Diabetes.
Clinical Place
The most advanced basal insulin. The absolute best choice for shift workers or teenagers with chaotic schedules who cannot take their insulin at the exact same time every day.