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Progestin·Endocrinology - Women's Health
Emergency contraception, continuous contraception, heavy menstrual bleeding (Mirena)
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High risk: Emergency Dose
1.5 mg STAT
Half-life
24 h
Caution: BMI > 70kg
DOUBLE DOSE
VTE Risk
SAFE
Avoid / Cautions
Known/suspected pregnancy, active breast cancer, severe liver disease or liver tumours, and unexplained vaginal bleeding need review before use. For emergency contraception, efficacy falls with delay, higher body weight, and enzyme-inducing medicines.
Overview
Potent, highly stable synthetic progestogen. Used as the 'Morning After Pill', the active hormone in the Mirena IUD, and the 'Mini-Pill'. Thickens cervical mucus and halts ovulation.
Clinical Focus
Extremely safe regarding cardiovascular/clotting risk. The emergency contraceptive pill must be taken within 72 hours of unprotected intercourse.
Bottom Line
Levonorgestrel is used in progestogen-only pills, IUDs, and emergency contraception, but the emergency dose must be taken within 72 hours and efficacy decreases significantly with delay.
Brand Names
Postinor-1, Levonelle (Emergency). Microlut (Mini-Pill). Mirena (IUD).
Oral Routes
Tablets (1.5 mg, 30 mcg).
Prescribing & PBS
Emergency Contraception is Over The Counter (S3). IUD/Mini-Pill is S4.
Primary
Emergency contraception, continuous contraception, heavy menstrual bleeding (Mirena).
Clinical Place
The Mirena IUD is the absolute gold standard for treating heavy/painful periods and providing highly reliable, 'forget-proof' contraception.
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