Loading
Progestin·Endocrinology - Women's Health
Long-term contraception, heavy menstrual bleeding, endometriosis, endometrial protection in HRT
Max Dose
150 mg/12W (IM)
Half-life
50 DAYS (IM)
Bone Loss
BLACK BOX
Weight Gain
HIGH RISK
Overview
Highly potent synthetic progestin. Most famously used as a 3-monthly contraceptive injection (Depo-Provera). Also used orally for menstrual regulation and endometriosis.
Maximum Dose
Max 150 mg every 12 weeks (IM).
Clinical Focus
Depot medroxyprogesterone can reduce bone mineral density; reassess long-term use, especially in adolescents or osteoporosis risk. Delayed return to fertility is common after stopping.
Bottom Line
Medroxyprogesterone is a progestogen used for contraception (depot injection) and HRT, but the depot form causes significant bone density loss and delayed return of fertility.
Brand Names
Depo-Provera (IM), Provera (Oral), Ralovera
Parenteral
Vials/Pre-filled syringes (150 mg/1 mL) for deep IM or SC injection.
Oral Routes
Tablets (2.5, 5, 10, 100 mg).
Prescribing & PBS
Unrestricted General Benefit (S4).
Primary
Long-term contraception, heavy menstrual bleeding, endometriosis, endometrial protection in HRT.
Clinical Place
The definitive 'forget-proof' contraceptive injection. Often stops periods entirely (amenorrhea) after the first few doses.