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FGA / Thioxanthene·Psychiatry - Oral Antipsychotics
Schizophrenia and other psychoses, especially when accompanied by severe agitation, restlessness, or hostility
Max Dose
150 mg/day
Half-life
20 h
Sedation
MODERATE
EPS Risk
HIGH
Overview
Oral tablet formulation of Zuclopenthixol. Potent FGA used for acute and chronic schizophrenia, particularly when patients exhibit significant aggression or agitation.
Maximum Dose
Max 150 mg/day (Usually 20-40 mg/day).
Clinical Focus
Often used as the oral 'trial' to ensure the patient tolerates the drug before locking them into the 4-weekly Clopixol Depot injection.
Bottom Line
Zuclopenthixol is a thioxanthene antipsychotic for schizophrenia and aggressive behaviour, but causes significant extrapyramidal effects and has depot formulations with prolonged irreversible action.
Brand Names
Clopixol
Oral Routes
Tablets (10 mg, 25 mg).
Prescribing & PBS
Authority Required (PBS).
Primary
Schizophrenia and other psychoses, especially when accompanied by severe agitation, restlessness, or hostility.
Clinical Place
The foundational oral step before transitioning to Clopixol Depot or Acuphase.