Depressive disorder due to another medical condition
Prominent depressive episode directly attributable to physiological effects of a medical condition
Prominent depressive episode directly attributable to physiological effects of a medical condition
Intoxication: recent stimulant use; Withdrawal: cessation/reduction after prolonged heavy use
≥5 of 9 SIG-E-CAPS symptoms for ≥2 weeks; ≥1 must be depressed mood or anhedonia
Marked incongruence between one's experienced/expressed gender and assigned gender, ≥6 months; in adolescents/adults: ≥2 of: incongruence between experienced gender and primary/secondary sex characteristics; strong desire to be rid of primary/secondary sex characteristics; strong desire for sex characteristics of experienced gender; strong desire to be of experienced gender; strong desire to be treated as experienced gender; strong conviction of having typical feelings/reactions of experienced gender
Death of someone close to the bereaved person ≥12 months ago (≥6 months in children/adolescents)
Predominant complaint of dissatisfaction with sleep quantity/quality: ≥1 of: difficulty initiating sleep; difficulty maintaining sleep (frequent awakenings); early morning awakening with inability to return to sleep
Presence of obsessions (recurrent/persistent intrusive thoughts/urges/images + attempts to suppress or neutralise), compulsions (repetitive behaviours/mental acts driven by rigid rules aimed at reducing distress/feared event), or both
Persistent personality disturbance representing a change from the individual's previous characteristic personality pattern
Intoxication: reversible substance-specific syndrome due to recent ingestion; Withdrawal: substance-specific syndrome due to cessation/reduction after heavy/prolonged use
Exposure to actual/threatened death, serious injury, or sexual violence (same exposure types as PTSD Criterion A)
Emotional or behavioural symptoms in response to an identifiable stressor, within 3 months of stressor onset
Criteria met for major or mild NCD (substantial or modest cognitive decline in ≥1 domain)
Restriction of energy intake → significantly low body weight for age, sex, developmental trajectory, and physical health
Prominent anxiety, panic attacks, or obsessions/compulsions directly attributable to physiological effects of another medical condition
Pervasive pattern of social inhibition, feelings of inadequacy, and hypersensitivity to negative evaluation, beginning by early adulthood; ≥4 of 7: avoids occupational activities involving interpersonal contact due to fears of criticism; unwilling to get involved unless certain of being liked; shows restraint in intimate relationships due to fear of shame; preoccupied with being criticised/rejected; inhibited in new interpersonal situations; views self as socially inept/unappealing/inferior; unusually reluctant to take risks or engage in new activities
Recurrent binge eating episodes associated with ≥3 of: eating faster; eating until uncomfortably full; eating large amounts when not physically hungry; eating alone due to embarrassment; feeling disgusted/depressed/guilty afterwards
Pervasive pattern of instability of interpersonal relationships, self-image, and affect, with marked impulsivity beginning by early adulthood; ≥5 of 9: frantic efforts to avoid abandonment; unstable intense relationships; identity disturbance; impulsivity in ≥2 damaging areas; suicidal/self-mutilating behaviour; affective instability; chronic emptiness; inappropriate intense anger; transient stress-related paranoia/dissociation
Intoxication: recent cannabis use with clinically significant maladaptive behavioural/psychological changes; Withdrawal: cessation/reduction of heavy prolonged use
≥3 of 12 catatonia symptoms: stupor; catalepsy; waxy flexibility; mutism; negativism; posturing; mannerism; stereotypy; agitation; grimacing; echolalia; echopraxia
Evidence by polysomnography of ≥5 central apnoeas per hour of sleep
Persistent or recurrent pattern of sleep disruption primarily due to alteration of the circadian system or misalignment between endogenous circadian rhythm and sleep-wake schedule
Disturbance of attention (reduced ability to direct, focus, sustain, shift attention) and awareness (reduced orientation to environment)
≥1 month of ≥1 delusion(s)
Pervasive and excessive need to be taken care of, leading to submissive and clinging behaviour and fears of separation, beginning by early adulthood; ≥5 of 8: difficulty making everyday decisions without advice/reassurance; needs others to assume responsibility for major areas of life; difficulty expressing disagreement out of fear; difficulty initiating projects alone; goes to excessive lengths to obtain nurturance/support; feels uncomfortable/helpless when alone; urgently seeks a replacement relationship when one ends; preoccupied with fears of being left to care for self
Acquisition and execution of coordinated motor skills is substantially below expected for chronological age and opportunity for skill learning
Severe recurrent temper outbursts (verbal or behavioural), grossly disproportionate to situation, ≥3×/week
Recurrent skin picking resulting in skin lesions
≥1 symptom of altered voluntary motor or sensory function
Persistent or recurrent difficulties with ≥1 of: vaginal penetration during intercourse; marked vulvovaginal or pelvic pain during intercourse or penetration attempts; marked fear/anxiety about vulvovaginal or pelvic pain in anticipation of, during, or as a result of vaginal penetration; marked tensing or tightening of pelvic floor muscles during vaginal penetration attempts
Failure to meet expected developmental milestones in several areas of intellectual functioning; applies to individuals <5 years when severity cannot be reliably assessed
Self-reported excessive sleepiness (hypersomnolence) despite main sleep period of ≥7 hrs; ≥1 of: recurrent lapses into sleep during same day; prolonged main sleep episode (>9 hrs) that is non-restorative; difficulty being fully awake after abrupt awakening
Recurrent outbursts of failure to control aggressive impulses; ≥1 of: verbal aggression or physical aggression toward property/animals/individuals ≥2×/week (on average) for ≥3 months; ≥3 aggressive outbursts involving damage/injury within a 12-month period
Substantial cognitive decline in ≥1 domain (complex attention, executive function, learning/memory, language, perceptual-motor, social cognition) based on concern + objective evidence
Persistently or recurrently deficient (or absent) sexual/erotic thoughts or fantasies AND desire for sexual activity; clinician judges deficiency considering age and general/sociocultural context
Abnormal and prolonged contraction of muscles of eyes, face, neck, limbs, or trunk developing in association with medication use
Parkinsonian tremor, muscular rigidity, or akinesia developing in association with medication use (most commonly neuroleptic/antipsychotic or dopamine-depleting agent)
Modest cognitive decline in ≥1 domain (concern of individual, knowledgeable informant, or clinician; supported by objective performance evidence)
Criteria met for major or mild NCD
Criteria met for major or mild NCD
Criteria met for major or mild NCD
Evidence by polysomnography of ≥5 obstructive apnoeas/hypopnoeas per hour of sleep + ≥1 of: nocturnal breathing disturbances (snoring, snorting, gasping, breathing pauses); daytime sleepiness/fatigue/unrefreshing sleep not explained by another disorder; OR ≥15 obstructive apnoeas/hypopnoeas per hour of sleep regardless of accompanying symptoms
Intoxication: recent opioid use; Withdrawal: cessation/reduction after heavy prolonged use, or administration of opioid antagonist
≥4 symptoms from: angry/irritable mood (loses temper; touchy/easily annoyed; angry/resentful); argumentative/defiant behaviour (argues with authority; defies rules; deliberately annoys; blames others); or vindictiveness — for ≥6 months, exhibited during interaction with ≥1 non-sibling individual
Medication-induced movement symptoms causing clinically significant distress or impairment
Symptoms characteristic of a depressive disorder causing clinically significant distress/impairment
Symptoms characteristic of a feeding/eating disorder causing clinically significant distress/impairment
Symptoms characteristic of an OCD-related disorder causing clinically significant distress/impairment
Symptoms characteristic of a sexual dysfunction causing clinically significant distress
Symptoms characteristic of a somatic symptom/related disorder causing clinically significant distress/impairment
Symptoms characteristic of a trauma/stressor-related disorder causing clinically significant distress/impairment
Symptoms characteristic of a bipolar/related disorder causing clinically significant distress/impairment
Over ≥6 months, recurrent, intense sexually arousing fantasies, urges, or behaviours involving sexual activity with a prepubescent child or children (generally ≤13 years)
Depressed mood most of the day, more days than not, for ≥2 years (≥1 yr children/adolescents)
Exposure to actual/threatened death, serious injury, or sexual violence (direct, witnessed, learning about close person, or repeated indirect exposure)
≥5 symptoms in final week before menses, improve within days of onset, become minimal/absent post-menses
Prominent hallucinations or delusions
Uninterrupted period of illness including a major mood episode (MDE or manic) concurrent with Schizophrenia Criterion A symptoms
Pervasive pattern of detachment from social relationships and restricted range of emotional expression, beginning by early adulthood; ≥4 of 7: neither desires nor enjoys close relationships; almost always chooses solitary activities; little/no interest in sexual experiences; few/no pleasurable activities; lacks close friends; appears indifferent to praise/criticism; shows emotional coldness/detachment/flat affect
≥2 of: delusions; hallucinations; disorganised speech; grossly disorganised/catatonic behaviour; negative symptoms — ≥1 must be delusions, hallucinations, or disorganised speech
Same symptom criteria as Schizophrenia (≥2 of the 5 symptom clusters; ≥1 must be delusions, hallucinations, or disorganised speech)
Intoxication: recent sedative/hypnotic/anxiolytic use; Withdrawal: cessation/reduction after prolonged heavy use
Persistent difficulties in social use of verbal/nonverbal communication; ≥1 of: deficits in using communication for social purposes; inability to change communication to match context; difficulty following rules for conversations and storytelling; difficulty understanding what is not explicitly stated
≥1 somatic symptom that is distressing or results in significant disruption of daily life
Prominent hallucinations or delusions
Involuntary movements (tardive dystonia: sustained/repetitive muscle contractions; tardive akathisia: subjective restlessness + repetitive movements) developing in association with neuroleptic use, persisting ≥4 weeks
Symptoms characteristic of a bipolar/related disorder causing clinically significant distress/impairment